Methanol → HCID 66661927, compound

HRID 557931Notes

Reaction equation

HRID 557931 reaction equation
C([N:8]1[CH2:12][CH:11]([CH2:13][OH:14])[CH:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[OH:21])[CH2:9]1)C1C=CC=CC=1.CO>[Pd]>[OH:14][CH2:13][C@H:11]1[CH2:12][NH:8][CH2:9][C@H:10]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[OH:21]

Participants

4

Reactant 2

HCID 887MethanolHCID 19694419HCID 19694419, compound

Product 1

HCID 66661927HCID 66661927, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 2-[1-benzyl-4-(hydroxymethyl)pyrrolidin-3-yl]phenol (101.4 mg, 0.0003580 mol) and palladium (10% on carbon, 75 mg) in methanol (5.0 mL, 0.12 mol) was stirred under hydrogen (balloon) overnight. The mixture was filtered and the filtrate was concentrated. The residue was used in next step without further purification.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was used in next step without further purification

Sources & evidence

ORD record
ord-d005f8ee382949a79e7d448a77b98916
Source dataset
uspto-grants-2011_11
Patent number
US08058288B2

Reaction notes

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