5-Boronothiophene-2-carboxylic acid → HCID 56961058, compound

HRID 55795Notes

Reaction equation

HRID 55795 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([OH:12])[CH:8]=2)[N:3]=1.B([C:16]1[S:20][C:19]([C:21]([OH:23])=[O:22])=[CH:18][CH:17]=1)(O)O>>[OH:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([C:16]1[S:20][C:19]([C:21]([OH:23])=[O:22])=[CH:18][CH:17]=1)[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 27798075-Boronothiophene-2-carboxylic acidHCID 221325772-Chloroquinolin-6-ol

Product 1

HCID 56961058HCID 56961058, compound

Procedure

Followed Scheme 3: Starting Materials: 2-chloroquinolin-6-ol and 5-boronothiophene-2-carboxylic acid. 1H NMR (CD3OD, 400 MHz): δ 8.25 (d, J=8.8 Hz, 1H), 7.97 (dd, J=9.2, 3.2 Hz, 2H), 7.88-7.82 (m, 2H), 7.41 (dd, J=9.2, 2.8 Hz, 1H), 7.19 (d, J=2.4 Hz, 1H). MS (ESI): m/z 271.6 [M+H]+.

Sources & evidence

ORD record
ord-24cf79426c2c4683850126bf6a144d08
Source dataset
uspto-grants-2016_09
Patent number
US09433618B2

Reaction notes

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