2-Chloroquinolin-6-ol → Methyl 4-(6-hydroxyquinolin-2-yl)cyclohex-3-enecarboxylate

HRID 55796Notes

Reaction equation

HRID 55796 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([OH:12])[CH:8]=2)[N:3]=1.CC1(C)C(C)(C)OB([C:21]2[CH2:26][CH2:25][CH:24]([C:27]([O:29][CH3:30])=[O:28])[CH2:23][CH:22]=2)O1>>[OH:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([C:21]1[CH2:26][CH2:25][CH:24]([C:27]([O:29][CH3:30])=[O:28])[CH2:23][CH:22]=1)[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 221325772-Chloroquinolin-6-olHCID 66980107Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate

Product 1

HCID 66980073Methyl 4-(6-hydroxyquinolin-2-yl)cyclohex-3-enecarboxylate

Procedure

Followed Scheme 3: Starting Materials: 2-chloroquinolin-6-ol and methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate.

Sources & evidence

ORD record
ord-1fd770a70c3c4c6482b925ff4de26417
Source dataset
uspto-grants-2016_09
Patent number
US09433618B2

Reaction notes

Loading…