Thionyl Chloride → HCID 86602288, compound

HRID 557971Notes

Reaction equation

HRID 557971 reaction equation
[ClH:1].Cl.[N:3]1([C:7]2[N:12]=[CH:11][C:10]([C:13]3([C:16]([OH:18])=O)[CH2:15][CH2:14]3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4]1.S(Cl)([Cl:21])=O>>[ClH:21].[ClH:1].[N:3]1([C:7]2[N:12]=[CH:11][C:10]([C:13]3([C:16]([Cl:21])=[O:18])[CH2:15][CH2:14]3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 66661792HCID 66661792, compound

Product 1

HCID 86602288HCID 86602288, compound

Procedure

To 1-(6-azetidin-1-ylpyridin-3-yl)cyclopropanecarboxylic acid dihydrochloride (61.00 mg, 0.0002095 mol) were added thionyl chloride (1.00 mL, 0.0137 mol) at 0° C. and the resulting solution was stirred at rt for 1 hr. Upon completion, the reaction mixture was azeotroped with toluene (3×) and then used in the next step without further purification.

Workup

  1. customUpon completion, the reaction mixture was azeotroped with toluene (3×)
  2. customused in the next step without further purification

Sources & evidence

ORD record
ord-1b0ca47f86d148438c484ad1f91ccbe5
Source dataset
uspto-grants-2011_11
Patent number
US08058288B2

Reaction notes

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