HCID 11503270, compound → HCID 11695677, compound

Participants

Reaction Steps

To compound 23 (305 mg, 0.68 mmol) dissolved in THF (6 mL), TREAT-HF (0.55 ml, 3.38 mmol) was added. The mixture was stirred at rt overnight. Concentration and chromatography (10:1→0:1 toluene-EtOAc) gave 35 (171 mg, 0.51 mmol, 75%); 13C NMR δ 14.7 (SCH2CH3), 20.6, 20.8 (CH3CO), 25.4 (SCH2CH3), 61.3, 63.0, 66.6, 71.1, 71.3 (C-2-6), 82.2 (C-1), 170.0, 170.6 (CH3CO); 1H NMR δ 1.26-1.30 (t, 3H), 2.05 (s, 3H), 2.08 (s, 3H), 2.32 (s, 1H), 2.56-2.68 (m, 2H), 3.58-3.67 (m, 2H), 4.09-4.14 (m, 2H), 5.24-5.35 (m, 3H).

Provenance & Evidence