HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-4-methoxycarbonylphenylboronic acid, pinacol ester → 4-(6-Hydroxyquinolin-2-yl)-3-methylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-4-methoxycarbonylphenylboronic acid, pinacol ester | HCID 11087024 | — |
| Reactant | 2-Chloroquinolin-6-ol | HCID 22132577 | — |
| Product | 4-(6-Hydroxyquinolin-2-yl)-3-methylbenzoic acid | HCID 66980047 | — |
Reaction Steps
Followed Scheme 3: Starting Materials: 2-chloroquinolin-6-ol and methyl 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate. 1H NMR (DMSO-d6, 400 MHz): δ 10.45 (brs, 1H), 8.61-8.46 (m, 1H), 8.03 (d, J=8.8 Hz, 1H), 7.96 (s, 1H), 7.92 (d, J=8.0 Hz, 1H), 7.78 (d, J=8.8 Hz, 1H), 7.66 (d, J=8.0 Hz, 1H), 7.50 (d, J=8.0 Hz, 1H), 7.35 (s, 1H), 2.42 (s, 3H). MS (ESI): m/z 279.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09433618B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-1e450f8fa336456e9f199151c4e059cc |
| Source note | uspto-grants-2016_09 |