HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Bromo-2,2-difluoroethyl pivalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | 2-Bromo-2,2-difluoroethan-1-ol | HCID 18368476 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Bromo-2,2-difluoroethyl pivalate | HCID 57817345 | — |
Reaction Steps
Pivalic chloride and 2-bromo-2,2-difluoroethanol were mixed in tetrahydrofuran and ice cooled. Triethylamine was added to the mixture. Subsequent standard separatory operation and solvent distillation gave 2-bromo-2,2-difluoroethyl pivalate. This compound was converted into a sodium sulfinate using sodium dithionite and then oxidized with hydrogen peroxide, yielding the target compound, sodium 2-(pivaloyloxy)-1,1-difluoroethanesulfonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08062828B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-9c40d4df90064dec910bb32118f834a3 |
| Source note | uspto-grants-2011_11 |