HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 6-Methacryloyl-2-oxohexahydro-3,5-methano-2h-cyclopenta[b]furan-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | tert-Butyl Formate | HCID 61207 | — |
| Reactant | Tert-butyl 6-methacryloyl-2-oxohexahydro-3,5-methano-2h-cyclopenta[b]furan-7-carboxylate | HCID 67000815 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 6-Methacryloyl-2-oxohexahydro-3,5-methano-2h-cyclopenta[b]furan-7-carboxylic acid | HCID 67000975 | 90% |
Reaction Steps
In 80 g of formic acid was dissolved 20.0 g of the methacrylate obtained in Example 1-1-1. The solution was stirred at room temperature overnight. Toluene was added to the reaction solution, from which formic acid and tert-butyl formate were azeotroped off. Recrystallization from hexane yielded 14.7 g of the target compound (yield 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08062831B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0f0127ec0e874036a27aee9e6081cc9c |
| Source note | uspto-grants-2011_11 |