Hexane → HCID 86633032, compound

Participants

Reaction Steps

2-Methyl-1-methylthiocarbonyloxypropyl butanoate (2d) (1 g) was dissolved in 20 mL of MTBE, saturated with 1% of water, 1.3 g of PLE/MPEG (7.5% , 60 mg/1 g) was added, and the mixture shaken at room temperature for 24 hrs. Hexane was added to the reaction mixture and after filtration through a CELITE® 545 pad, the organic solution was washed with water, aqueous sodium bicarbonate (NaHCO3) and brine, and dried over anhydrous sodium sulfate (Na2SO4). After evaporating the solvent under reduced pressure the title compound (14) was obtained (0.29 g, 58% yield). The absolute configuration was determined by derivatization to a compound having known stereochemistry.

Provenance & Evidence