反应详情

A 20-L, multi-necked, cylindrical reactor, fitted with a mechanical stirrer, a nitrogen inlet and an outlet connected to an oxidation bath, and a bleach bath (14% NaOCl) to oxidize librated methanethiol and acetaldehyde is charged with racemic 2-methyl-1-methylthiocarbonyloxypropyl 2-methylpropanoate (2b) (5.32 kg, 25.8 mol) and 0.8 M phosphate buffer (10 L, pH 7.0). Solid supported Candida antarctica lipase A (125 g, NOVOZYME® 735, NOVOZYME®; CHIRAZYME™ L-5, Roche Diagnostics; or other suppliers) is slowly added while stirred. The reaction mixture is stirred at room temperature (22-24° C.) for ca. 18 hours.

1. customconnected to an oxidation bath, and a bleach bath
2. additionis slowly added
3. stirringThe reaction mixture is stirred at room temperature (22-24° C.) for ca. 18 hours