3,5-dichloro-2-amino-N-(2-hydroxyethoxy)benzamide → 3-(3,5-Dichloro-2-aminophenyl)-5,6-dihydro-1,4,2-dioxazine

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Reaction Steps

At 20° C., 30 ml of thionyl chloride are initially charged and 3 g of 3,5-dichloro-2-amino-N-(2-hydroxyethoxy)benzamide are added in 3 portions with stirring. The mixture is stirred at 70° C. for 12 h. The reaction mixture is then cooled and carefully poured onto ice-water. The mixture is extracted twice with in each case 150 ml of dichloromethane and the extracts are dried with sodium sulphate and evaporated to dryness using a rotary evaporator.

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