HCID 178424719, compound → HCID 178424718, compound

HRID 558068Notes

Reaction equation

HRID 558068 reaction equation
[CH3:1][C:2]1[C:3]([N+:14]([O-])=O)=[C:4]([C:8]2[NH:13][CH2:12][CH2:11][O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1>C(O)C.[Pd]>[O:10]1[CH2:11][CH2:12][NH:13][C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=2[NH2:14])=[N:9]1

Participants

4

Reactant 1

HCID 178424719HCID 178424719, compound

Product 1

HCID 178424718HCID 178424718, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
21 °C

Procedure

3 g (13.6 mmol) of 3-(3-methyl-2-nitrophenyl)-5,6-dihydro-4H-[1,2,4]oxadiazine are dissolved in 40 ml of ethanol, and 0.3 g of Pd/C (5%) is added. The mixture is then stirred at 21° C. under a hydrogen pressure of 3 bar for 72 h. The reaction mixture is then filtered and the ethanol is distilled off under reduced pressure.

Workup

  1. filtrationThe reaction mixture is then filtered
  2. distillationthe ethanol is distilled off under reduced pressure

Sources & evidence

ORD record
ord-bc51cd816f244ca2b71609018c74e937
Source dataset
uspto-grants-2011_11
Patent number
US08062995B2

Reaction notes

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