Formaldehyde → HCID 67000936, compound

Participants

Reaction Conditions

Reaction Steps

step 1—A suspension of 3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)-phenoxy]-5-chloro-benzonitrile (R-73, 1.32 g, 2.88 mmol), 37% aqueous formaldehyde (100 mL) and MeOH (100 mL) was stirred at 67° C. for 35 h. The volatile solvents were evaporated and the residue diluted with H2O and the resulting precipitate filtered, washed with H2O and air-dried to afford 1.27 g of 3-[6-bromo-2-fluoro-3-(1-hydroxymethyl-1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)-phenoxy]-5-chloro-benzonitrile (12).

Provenance & Evidence