Ditert-butyl phosphate → HCID 67001773, compound

Participants

Reaction Steps

step 2—To a mixture of 16 (1.28 g, 2.54 mmol), di-tert-butylphosphate (1.06 g, 5.08 mmol), in MeCN (70 mL) was added Ag2O (0.59 g, 2.54 mmol) and the resulting mixture was stirred for 1 d at RT. The resulting mixture was filtered through CELITE®, the filtrate was evaporated and the crude product purified by SiO2 chromatography eluting with a MeOH/DCM gradient (0 to 1% MeOH) to afford 1.1 g of phosphoric acid 3-[4-bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-benzyl]-pyrazolo[3,4-b]pyridin-1-ylmethyl ester di-tert-butyl ester (18)

Provenance & Evidence