HCID 18756317, compound → HCID 66999661, compound

HRID 558078Notes

Reaction equation

HRID 558078 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:20]=[C:21](C#N)[CH:22]=1)[O:6][C:7]1[C:8]([F:19])=[C:9]([CH2:15][C:16]([OH:18])=[O:17])[CH:10]=[CH:11][C:12]=1[O:13][CH3:14])#[N:2].C(C1C=C(C=C(C(F)F)C=1)OC1C(F)=C(CC(O)=O)C=CC=1OC)#N.CN1C2C(C(OC)=O)C(OC(C3C=CC(F)=CC=3)C3C=CC(F)=CC=3)CC1CC2.[Cl:79]C1C=C(C=C(O)C=1)C#N>>[Cl:79][C:21]1[CH:20]=[C:5]([CH:4]=[C:3]([C:1]#[N:2])[CH:22]=1)[O:6][C:7]1[C:8]([F:19])=[C:9]([CH2:15][C:16]([OH:18])=[O:17])[CH:10]=[CH:11][C:12]=1[O:13][CH3:14]

Participants

5

Reactant 4

HCID 18756317HCID 18756317, compoundHCID 219498783-Chloro-5-hydroxybenzonitrileHCID 66999036HCID 66999036, compoundHCID 66999560HCID 66999560, compound

Product 1

HCID 66999661HCID 66999661, compound

Procedure

[3-(3,5-Dicyano-phenoxy)-2-fluoro-4-methoxy-phenyl]-acetic acid (R-45) and [3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-4-methoxy-phenyl]-acetic acid (R-46) can be prepared similarly except R-10 and R-26 respectively are used in place of 3-chloro-5-hydroxy-benzonitrile.

Sources & evidence

ORD record
ord-1481b35ddd9a4328ac69905f3cc99d95
Source dataset
uspto-grants-2011_11
Patent number
US08063028B2

Reaction notes

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