Hydrochloric Acid → 2-(2-Bromo-4-chlorophenyl)-2-fluoroethanamine, hydrochloride

Participants

Reaction Conditions

Reaction Steps

Dissolve 2-(2-bromo-4-chlorophenyl)-2-fluoroacetonitrile (2.45 g, 9.86 mmol) in THF (50 mL). Cool the mixture to 0° C., then add BH3-THF complex (1 N, 20 mL, 20 mmol), and stir overnight. Add ethanol (5 mL) and then adjust to acidic with an ethanolic HCl solution. After removing the solvent, add DCM (20 mL) to the solid. Filter and wash with DCM, and dry to give the title compound as the HCl salt. MS (ES) m/z 254 [M+1]+.

Provenance & Evidence