HuagongsheHuagongshe Chemistry Print Report · For research reference only
Simtuzumab → 3-Chloro-4-(4-fluoro-6-hydroxyquinolin-2-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Simtuzumab | HCID 17750227 | — |
| Reactant | 2-Chloro-4-fluoro-6-methoxyquinoline | HCID 86689935 | — |
| Product | 3-Chloro-4-(4-fluoro-6-hydroxyquinolin-2-yl)benzoic acid | HCID 56959069 | — |
Reaction Steps
Followed Scheme 2, B conditions starting with 2-chloro-4-fluoro-6-methoxyquinoline (Intermediate 7) and 4-carboxy-2-chlorophenylboronic acid. 1H NMR (MeOD 400 MHz): δ 8.20 (d, J=1.2 Hz, 1H), 8.10 (dd, J=8.0, 1.6 Hz, 1H), 8.02 (d, J=9.2, 1.2 Hz, 1H), 7.75 (d, J=8.0 Hz, 1H), 7.52-7.45 (m, 2H), 7.47 (d, J=2.4 Hz, 1H). MS (ESI): m/z 317.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09433618B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-7c716fd3836f4e84a9ad8c349c6bb0d0 |
| Source note | uspto-grants-2016_09 |