反应详情

Followed the two step synthesis shown in Scheme 1 starting with 2-chloro-6-methoxyquinoline and 5-cyanothiophen-2-ylboronic acid, with minor variations: the base used in step 1 was sodium carbonate and the solvent was DME (dimethoxyethane)/water. In step 2, after quenching w/ice water, a standard ethyl acetate extraction was preformed followed by purification by prep-TLC (PE: EA=1:1).

1. customthe two step synthesis
2. customIn step 2, after quenching w/ice water
3. extractiona standard ethyl acetate extraction
4. customwas preformed followed by purification by prep-TLC (PE: EA=1:1)