Sodium Hydroxide → HCID 59272469, compound

Participants

Reaction Steps

Heat a mixture of N-(2-(2-(2-(2-(2-(1H-1,2,3-triazol-1-yl)ethylamino)-5-fluoropyrimidin-4-yl)benzo[b]thiophen-7-yl)-4-fluorophenyl)propan-2-yl)formamide (120 mg, 231 μmol) and sodium hydroxide (5 N, 10 mL, 50 mmol) in ethanol (10 mL) at 80° C. for 3 h. Dilute the mixture with ice water and extract with chloroform/IPA (3/1, 100 mL). Wash the organic phase with water/aqueous saturated sodium chloride, dry over sodium sulfate, and concentrate in vacuo. Purify the crude product by FCC (DCM to chloroform/methanol/ammonium hydroxide 7/3/0.05 as gradient) to give the title compound as a grey solid (82 mg, 75%). MS (ES) m/z 492 [M+1]+.

Provenance & Evidence