Sulfuric Acid → HCID 59152579, compound

HRID 558171Notes

Reaction equation

HRID 558171 reaction equation
[Br:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[C:4]([NH:6][NH:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[S:9])=O.S(=O)(=O)(O)O>C(O)C>[Br:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[C:4]1[S:9][C:8]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][N:6]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 5228672HCID 5228672, compound

Product 1

HCID 59152579HCID 59152579, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1-(2-bromobenzoyl)-4-phenylthiosemicarbazide (250 mg, 0.71 mmol; Reference Compound 5-(6)) in ethanol (2.5 mL) was added concentrated sulfuric acid (0.5 mL) at room temperature, and then the mixture was refluxed for 30 minutes. The reaction solution was poured into ice water and the precipitated solid was filtered off. The solid was dried under a reduced pressure at 60° C. to give 210 mg (87%) of the titled compound as a colorless solid.

Workup

  1. temperaturethe mixture was refluxed for 30 minutes
  2. filtrationthe precipitated solid was filtered off
  3. customThe solid was dried under a reduced pressure at 60° C.

Sources & evidence

ORD record
ord-37efe111367748c2b4489669cfe6e823
Source dataset
uspto-grants-2011_11
Patent number
US08063034B2

Reaction notes

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