HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 55818Generated: October 26, 2026
Sodium Carbonate → Methyl 4-(6-methoxyquinolin-2-yl)benzoate
https://huagongshe.com/reaction/55818
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Methoxycarbonylphenylboronic acid | HCID 2734369 | — |
| Reactant | HCID 178487824 | HCID 178487824 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | Methyl 4-(6-methoxyquinolin-2-yl)benzoate | HCID 66980098 | 40.9% |
Reaction Steps
A mixture of 2-chloro-6-methoxyquinoline (Intermediate 1, 200 mg, 1.0 mmol), 4-(methoxycarbonyl) phenylboronic acid (205 mg, 1.1 mmol), Pd(dppf)Cl2 (366 mg, 0.5 mmol) and sodium carbonate (212 mg, 2.0 mmol) in 1,4-dioxane/water (3 mL/0.6 mL) was heated to 120° C. by microwave for 1 h. The precipitates were filtered; washed with EA (10 mL), acetone (10 mL) and water (10 mL) separately; dried to afford product (120 mg, 40.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09433618B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-22fc8e2e1637487cbda154f2dea039f9 |
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| Source note | uspto-grants-2016_09 |
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