Hydrochloric Acid → HCID 25160469, compound

Participants

Reaction Steps

1-(2-(Tert-butyldimethylsilyloxy)ethyl)-N-(4-fluoro-5-(2-fluoro-4-iodophenylamino)-1-methyl-1H-benzo[d]imidazol-6-yl)cyclopropane-1-sulfonamide (39 mg, 0.06 mmoles) was dissolved in THF (0.5 ml) and aqueous hydrochloric acid (1.2 N, 0.5 ml) was added at 0° C. After stirring the reaction mixture for two hours, a saturated aqueous solution of sodium bicarbonate (5 ml) was added. The mixture was extracted with EtOAc (3×5 ml). The organic layers were combined, dried (Na2SO4) and concentrated under reduced pressure. The crude product was purified by flash chromatography using MeOH/CHCl3 (1/9) yielding to the title compound (27 mg, 83%). m/z=549 [M+1]−.

Provenance & Evidence