1-Bromo-2-butyne → 4-(2-butynyloxy)-3-N-(4-chlorophenyl)-isophthalamide

HRID 558326Notes

Reaction equation

HRID 558326 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:21])[C:10]2[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=2[O:19][CH3:20])[C:13]([NH2:15])=[O:14])=[CH:4][CH:3]=1.Br[CH2:23][C:24]#[C:25]C>>[CH2:20]([O:19][C:18]1[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][C:10]=1[C:9]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)=[O:21])[C:23]#[C:24][CH3:25]

Participants

3

Reactant 2

HCID 27568621-Bromo-2-butyneHCID 574017623-N-(4-chlorophenyl)-4-methoxyisophthalamide

Product 1

HCID 111520634-(2-butynyloxy)-3-N-(4-chlorophenyl)-isophthalamide

Procedure

The captioned compound was synthesized from 3-N-(4-chlorophenyl)-4-methoxyisophthalamide and 1-bromo-2-butyne by the same procedure as in the manufacturing method described in Example 1-1-2.

Sources & evidence

ORD record
ord-22767b572bba4fd3b6a488883da53d5a
Source dataset
uspto-grants-2011_11
Patent number
US08063046B2

Reaction notes

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