HCID 11381609, compound → HCID 59265141, compound

HRID 558338Notes

Reaction equation

HRID 558338 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH2:10])=[O:9])=[CH:6][C:5]=1[C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)=[O:14])([O-])=O.[H][H]>CO.[Pt]=O>[NH2:1][C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH2:10])=[O:9])=[CH:6][C:5]=1[C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)=[O:14]

Participants

5

Reactant 2

HCID 11381609HCID 11381609, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59265141HCID 59265141, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

4-Nitro-3-N-(4-chlorophenyl)-isophthalamide (46 mg) obtained in Example 1-2-20 was dissolved in 7 mL of methanol, and 10 mg of platinum oxide was added to the solution, followed by stirring the mixture for 30 minutes at room temperature in an atmosphere of hydrogen. The reaction mixture was filtered to remove insolubles, and the filtrate was concentrated under reduced pressure. The resulting solid was dried under reduced pressure to obtain 41 mg (99%) of 4-amino-3-N-(4-chlorophenyl)-isophthalamide.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customto remove insolubles
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe resulting solid was dried under reduced pressure

Sources & evidence

ORD record
ord-362f0afc8a124d8f9afa7933dc21e69d
Source dataset
uspto-grants-2011_11
Patent number
US08063046B2

Reaction notes

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