4-Chloro-2-fluoroaniline → 3-N-(4-chloro-2-fluorophenyl)-4-methoxyisophthalamide

HRID 558379Notes

Reaction equation

HRID 558379 reaction equation
[CH3:1][O:2][C:3]1[C:8]([C:9]([OH:11])=O)=[CH:7][C:6]([C:12]([NH2:14])=[O:13])=[CH:5][CH:4]=1.[Cl:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[C:18]([F:23])[CH:17]=1>>[Cl:15][C:16]1[CH:22]=[CH:21][C:19]([NH:20][C:9](=[O:11])[C:8]2[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=2[O:2][CH3:1])[C:12]([NH2:14])=[O:13])=[C:18]([F:23])[CH:17]=1

Participants

3

Reactant 2

HCID 938984-Chloro-2-fluoroanilineHCID 132228085-Carbamoyl-2-methoxybenzoic acid

Product 1

HCID 592650883-N-(4-chloro-2-fluorophenyl)-4-methoxyisophthalamide

Procedure

The captioned compound was synthesized from 6-methoxyisophthalamic acid and 4-chloro-2-fluoroaniline by the same procedure as in the manufacturing method described in step C of Example 1-3-1.

Sources & evidence

ORD record
ord-f953670ca5504e98a813e1dcebb957f1
Source dataset
uspto-grants-2011_11
Patent number
US08063046B2

Reaction notes

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