2-Butanamine, 1-methoxy- → 4-methoxy-N-(l-methoxymethyl-propyl)-3-[(E)-2-(4-trifluoromethoxyphenyl)-vinyl]-benzamide

HRID 558393Notes

Reaction equation

HRID 558393 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1/[CH:12]=[CH:13]/[C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=1.[NH2:25][CH:26]([CH2:30][CH3:31])[CH2:27][O:28][CH3:29]>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH:25][CH:26]([CH2:27][O:28][CH3:29])[CH2:30][CH3:31])=[O:8])=[CH:5][C:4]=1/[CH:12]=[CH:13]/[C:14]1[CH:15]=[CH:16][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 938372-Butanamine, 1-methoxy-HCID 231414984-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoic acid

Product 1

HCID 231415304-methoxy-N-(l-methoxymethyl-propyl)-3-[(E)-2-(4-trifluoromethoxyphenyl)-vinyl]-benzamide

Procedure

The captioned compound was synthesized from 4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoic acid obtained in step B of Example 2-2-1 and 2-amino-1-methoxybutane in accordance with the same procedure as in the methods described in step C of Example 1-2-3.

Sources & evidence

ORD record
ord-c4aa3cf92e21430abab0fea8c0bbf575
Source dataset
uspto-grants-2011_11
Patent number
US08063046B2

Reaction notes

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