Methylamine hydrochloride → 3-[(E)-2-(4-chlorophenyl)-vinyl]-4-methoxy-N-methyl-benzamide

HRID 558395Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=2[O:19][CH3:20])[C:13](O)=[O:14])=[CH:4][CH:3]=1.Cl.[CH3:22][NH2:23]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=2[O:19][CH3:20])[C:13]([NH:23][CH3:22])=[O:14])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6364545Methylamine hydrochloride

HCID 231413873-[(E)-2-(4-chlorophenyl)vinyl]-4-methoxy-benzoic acid

Product 1

HCID 231414833-[(E)-2-(4-chlorophenyl)-vinyl]-4-methoxy-N-methyl-benzamide

Procedure

The captioned compound was synthesized from 3-[(E)-2-(4-chlorophenyl)vinyl]-4-methoxy-benzoic acid and methylamine hydrochloride in accordance with the same procedure as in the manufacturing method described in step G of Example 1-2-1.

Sources & evidence

ORD record: ord-6819f009f06a4c4188dbd327614ba9a2
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063046B2

Reaction notes

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