Pyrrolidin-1-amine monohydrochloride → 4-methoxy-N-pyrrolidin-1-yl-3-[(E)-2-(4-trifluoromethoxyphenyl)-vinyl]benzamide

HRID 558403Notes

Reaction equation

HRID 558403 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][C:4]=1/[CH:12]=[CH:13]/[C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=1.Cl.[NH2:26][N:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH:26][N:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)=[O:9])=[CH:5][C:4]=1/[CH:12]=[CH:13]/[C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:23])([F:24])[F:22])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 3017392Pyrrolidin-1-amine monohydrochlorideHCID 231414984-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoic acid

Product 1

HCID 231413894-methoxy-N-pyrrolidin-1-yl-3-[(E)-2-(4-trifluoromethoxyphenyl)-vinyl]benzamide

Procedure

The captioned compound was synthesized from 4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoic acid obtained in step B of Example 2-2-1 and 1-aminopyrrolidine hydrochloride in accordance with the same procedure as in the methods described in step C of Example 1-2-3.

Sources & evidence

ORD record
ord-22841ef601c5418f91d9dc7b4fcf1acb
Source dataset
uspto-grants-2011_11
Patent number
US08063046B2

Reaction notes

Loading…