Diglycolamine → N-[2-(2-hydroxyethoxy)-ethyl]-4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)-vinyl]benzamide

HRID 558426Notes

Reaction equation

HRID 558426 reaction equation
OC(CO)[CH2:3][NH:4][C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8](/[CH:14]=[CH:15]/[C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)[CH:7]=1.NC[CH2:31][O:32][CH2:33][CH2:34][OH:35]>>[OH:35][CH2:34][CH2:33][O:32][CH2:31][CH2:3][NH:4][C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8](/[CH:14]=[CH:15]/[C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 13578DiglycolamineHCID 23141417N-(2,3-dihydroxy-propyl)-4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]benzamide

Product 1

HCID 23141488N-[2-(2-hydroxyethoxy)-ethyl]-4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)-vinyl]benzamide

Procedure

The captioned compound was synthesized from 4-methoxy-3-[(E)-2-(4-trifluoromethylphenyl)vinyl]benzoic acid obtained in step B of Example 2-2-38 and 2-(2-aminoethoxy)ethanol in accordance with the same procedure as in the methods described in step C of Example 1-2-3.

Sources & evidence

ORD record
ord-d508797c06e04fc6810ed0cda8548697
Source dataset
uspto-grants-2011_11
Patent number
US08063046B2

Reaction notes

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