HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-3-aminopropane-1,2-diol → (R)-N-(2,3-dihydroxy-propyl)-4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)-vinyl]-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-3-aminopropane-1,2-diol | HCID 6994409 | — |
| Reactant | 4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoic acid | HCID 23141498 | — |
| Product | (R)-N-(2,3-dihydroxy-propyl)-4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)-vinyl]-benzamide | HCID 59265118 | — |
Reaction Steps
The captioned compound was synthesized from 4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]-benzoic acid obtained in step B of Example 2-2-1 and (R)-3-amino-1,2-propanediol (produced by Wako Pure Chemical Industries) in accordance with the same procedure as in the methods described in step C of Example 1-2-3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063046B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-26109c8670fc4d0ea13c751122dd5723 |
| Source note | uspto-grants-2011_11 |