(2S)-2-amino-3-(tert-butoxy)propanoic acid → (S)-3-t-butoxy-2-{4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoylamino}propionic acid
Reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1/[CH:12]=[CH:13]/[C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=1.[C:25]([O:29][CH2:30][C@@H:31]([C:33]([OH:35])=[O:34])[NH2:32])([CH3:28])([CH3:27])[CH3:26]>>[C:25]([O:29][CH2:30][C@H:31]([NH:32][C:7](=[O:8])[C:6]1[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[C:4](/[CH:12]=[CH:13]/[C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:22])([F:24])[F:23])=[CH:16][CH:15]=2)[CH:5]=1)[C:33]([OH:35])=[O:34])([CH3:28])([CH3:26])[CH3:27]Participants
3
Procedure
The (S)-3-t-butoxy-2-{4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoylamino}propionic acid was synthesized from 4-methoxy-3-[(E)-2-(4-trifluoromethoxyphenyl)vinyl]benzoic acid obtained in step B of Example 2-2-1 and O-t-butyl-L-serine in accordance with the same procedure as in the methods described in step C of Example 1-2-3.
Sources & evidence
- ORD record
- ord-ee17cca66d0d4b5090b785e26b9f9b91
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08063046B2
Reaction notes
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