反应详情

The product from step (i) (40 g) was dissolved in 19% (w/w)-sodium butoxide in butanol (250 ml). The reaction mixture was stirred under reflux for 6 h. The resultant suspension was cooled to rt, diluted with water and extracted with diethyl ether. The combined organic phase was washed with water, dried and concentrated in vacuo. The subtitle compound was crystallized from diethyl ether/isohexane (1/1, 300 ml) and obtained by filtration. Yield 19 g.

1. temperatureunder reflux for 6 h
2. extractionextracted with diethyl ether
3. washThe combined organic phase was washed with water
4. customdried
5. concentrationconcentrated in vacuo
6. customThe subtitle compound was crystallized from diethyl ether/isohexane (1/1, 300 ml)
7. customobtained by filtration