2-Amino-2-methyl-1-propanol → 2-Chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiazole-5-sulfonamide

Participants

Role	Name	HCID	Charge
Reactant	2-Amino-2-methyl-1-propanol	HCID 11807	—
Reactant	2-Chloro-1,3-thiazole-5-sulfonyl chloride	HCID 16228943	—
Product	2-Chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiazole-5-sulfonamide	HCID 61052651	67.7%

Reaction Steps

Prepared by general procedure III from 2-chloro-thiazole-5-sulfonyl chloride (2.0 g, 9 mmol, example B.13, step 1) and 2-amino-2-methyl-1-propanol (0.95 g, 9 mmol) to give the title compound (1.65 g, 33%) as an off-white solid. MS (EI) 269.2 [(M)+] and 271.2 [(M+2)+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063048B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-21c083654c424422a29ffde614986cf8
Source note	uspto-grants-2011_11