反应详情

温度

23 °C

A mixture of 6-bromo-8-methyl-imidazo[1,2-a]pyridine (example C.20 step 1) (7.0 g, 33 mmol), commercially available 4-(trifluoromethyl)phenylboronic acid (6.929 g, 36 mmol), Pd(PPh3)4 (383 mg, 1 mol %) and 1M Na2CO3-solution (77 mL, 77 mmol) in DME (150 mL) was stirred at reflux for 1 h. Cooled to 23° C., diluted with water, extracted with EtOAc, washed the organic layer with brine, dried over MgSO4. Removal of the solvent in vacuum left a brown solid, which was purified by silica gel column chromatography with EtOAc/MeOH to give the title compound as a white solid (8.29 g, 91%). MS (ISP) 277.1 [(M+H)+].

1. temperatureat reflux for 1 h
2. extractionextracted with EtOAc
3. washwashed the organic layer with brine
4. dry with materialdried over MgSO4
5. customRemoval of the solvent in vacuum
6. waitleft a brown solid, which
7. customwas purified by silica gel column chromatography with EtOAc/MeOH