HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethane, 2-bromo-1,1-diethoxy- → 6-Bromoimidazo[1,2-a]pyridine-8-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| Reactant | 2-Amino-5-bromopyridine-3-carbonitrile | HCID 24229199 | — |
| Product | 6-Bromoimidazo[1,2-a]pyridine-8-carbonitrile | HCID 67001173 | 32% |
Reaction Steps
Prepared from 2-amino-5-bromo-nicotinonitrile (example C.23 step 1) (26 g, 131 mmol) and bromoacetaldehyde diethyl acetal (90%, 45 mL, 263 mmol) as described in example C.20 step 1. Obtained the title compound as a light brown solid (9.3 g, 32%). MS (ISP) 222.1 [(M+H)+], 224 [(M+2+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063048B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-c1ea817142a54b6785a5a753e19ff014 |
| Source note | uspto-grants-2011_11 |