2-Amino-5-bromopyridine → HCID 20099814, compound

HRID 558611Notes

Reaction equation

HRID 558611 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5](Br)=[CH:4][N:3]=1.[F:9][C:10]([F:21])([F:20])[C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[F:9][C:10]([F:21])([F:20])[C:11]1[CH:16]=[CH:15][C:14]([C:5]2[CH:6]=[CH:7][C:2]([NH2:1])=[N:3][CH:4]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 27343894-(Trifluoromethyl)phenylboronic acid

Product 1

HCID 20099814HCID 20099814, compoundYield 810.6%

Procedure

Prepared from commercially available 2-amino-5-bromopyridine (5.0 g, 29 mmol) and commercially available 4-trifluoromethylphenylboronic acid (6 g, 32 mmol) as described in example C.20 step 2. Obtained the title compound as an off-white solid (56 g, 56%). MS (ISP) 239.2 [(M+H)+].

Sources & evidence

ORD record
ord-12bb7cda034b46f599001af224dffd89
Source dataset
uspto-grants-2011_11
Patent number
US08063048B2

Reaction notes

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