5-Bromo-2,4-difluorobenzenesulfonamide → 2,4-Difluoro-5-[7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	5-Bromo-2,4-difluorobenzenesulfonamide	HCID 2773295	—
Reactant	3-Ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine	HCID 71539732	—
Product	2,4-Difluoro-5-[7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-benzenesulfonamide	HCID 11853036	—

Reaction Steps

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.1) (355 mg, 1.0 mmol) and commercially available 5-bromo-2,4-difluorobenzenesulphonamide (245 mg, 0.9 mmol) according to general procedure II. Obtained as a yellow solid (230 mg, 42%). MS (ISP) 614.3 [(M+H)+]; mp 281-284° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063048B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-82373d765a3b4b27ad730b20fdabd2c5
Source note	uspto-grants-2011_11