3-(4-Nitro-pyrazol-1-yl)-propan-1-ol → HCID 61668875, compound

HRID 55872Notes

Reaction equation

HRID 55872 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][CH2:11][OH:12])[CH:8]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][CH2:11][OH:12])[CH:8]=1

Participants

4

Reactant 1

HCID 196218373-(4-Nitro-pyrazol-1-yl)-propan-1-ol

Product 1

HCID 61668875HCID 61668875, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-(4-Nitro-pyrazol-1-yl)-propan-1-ol (1.41 g, 8.23 mmol) was dissolved in MeOH (15 mL). Pd/C (0.532 g, 0.82 mmol) was added and the mixture was stirred under H2 at rt for 16 hours. The reaction mixture was filtered and the solvent evaporated in vacuo to afford the title compound as a red/brown oil (1.18 g, 100%); LCMS, Rt=0.31 min (MeOH-FA method), m/z 142 (MH+).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-d868e22b24a142ae9bdc34d5a2d75a0d
Source dataset
uspto-grants-2016_09
Patent number
US09433622B2

Reaction notes

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