反应详情

A solution of 32 (0.25 g, 1.05 mmol) in MeOH (6 mL) was hydrogenated using 10% Pd/C (50 mg) under a hydrogen atmosphere (balloon pressure) at rt for 1 h. The reaction mixture was filtered through a Celite bed and the filtrate was evaporated to give the desired amine (0.2 g, 82%) as brown liquid. Rf: 0.1 (10% MeOH/DCM); m/z): 208 [MH]+; 1H NMR (400 MHz, DMSO-d6): δ 7.82 (1H, d, J=2.4 Hz), 7.01-6.99 (1H, m), 6.88-6.86 (1H, m), 5.16 (2H, br s), 3.93-3.80 (3H, m), 3.21-3.13 (5H, m), 2.65-2.61 (1H, m), 2.42-2.34 (2H, m), 1.99-1.92 (1H, m).

1. customat rt
2. customfor 1 h
3. filtrationThe reaction mixture was filtered through a Celite bed
4. customthe filtrate was evaporated