反应详情

To a stirred solution of 34 (0.35 g 1.0 mmol) in MeOH (6 mL) was added 10% Pd/C and hydrogenated under balloon pressure at rt for 2 h. The reaction mixture was filtered through Celite and the filtrate was evaporated to give the desired amine A4-9 (0.25 g, 78%) as a liquid. Rf: 0.1 (10% MeOH/CHCl3); (m/z): 330 [M+1]+; 1H NMR (400 MHz, CDCl3): δ 8.01 (1H, s), 7.07-6.94 (2H, m), 4.44 (2H, br s), 3.74-3.72 (2H, m), 3.33-3.31 (2H, m), 2.95-2.86 (3H, m), 2.06-2.01 (2H, m), 1.39 (9H, m).

1. filtrationThe reaction mixture was filtered through Celite
2. customthe filtrate was evaporated