HCID 67000839, compound → HCID 11852315, compound

HRID 558810Notes

Reaction equation

HRID 558810 reaction equation
[F:1][CH:2]([F:24])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]#[CH:13])=[C:7]2[N:6]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:4]=1.[C:25]([O:29][C:30](=[O:47])[NH:31][CH2:32][CH2:33][NH:34][S:35]([C:38]1[CH:43]=[C:42](Br)[C:41]([F:45])=[CH:40][C:39]=1[F:46])(=[O:37])=[O:36])([CH3:28])([CH3:27])[CH3:26]>>[C:25]([O:29][C:30](=[O:47])[NH:31][CH2:32][CH2:33][NH:34][S:35]([C:38]1[CH:43]=[C:42]([C:13]#[C:12][C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:1])[F:24])=[CH:4][C:5]([C:14]4[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=4)=[N:6][C:7]=23)[C:41]([F:45])=[CH:40][C:39]=1[F:46])(=[O:36])=[O:37])([CH3:28])([CH3:26])[CH3:27]

Participants

3

Reactant 2

HCID 67000839HCID 67000839, compoundHCID 866080343-Ethynyl-7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 11852315HCID 11852315, compound

Procedure

The title compound was prepared from 7-difluoromethyl-3-ethynyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.2) (675 mg, 2 mmol) and [2-(5-bromo-2,4-difluoro-benzenesulfonylamino)-ethyl]-carbamic acid tert-butyl ester (1080 mg, 2.6 mmol) according to general procedure II. Obtained as a yellow solid (670 mg, 50%). MS (ISP) 572.0 [(M+H)+]; mp 203-204° C. (dec.).

Sources & evidence

ORD record
ord-7b4ad2e9657949699eeb0584d30557e7
Source dataset
uspto-grants-2011_11
Patent number
US08063048B2

Reaction notes

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