HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Ethynylpyridin-2-amine → 5-[6-(4-Chloro-phenyl)-8-fluoro-imidazo[1,2-a]pyridin-3-ylethynyl]-pyridin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Ethynylpyridin-2-amine | HCID 21954827 | — |
| Reactant | 6-(4-Chloro-phenyl)-8-fluoro-3-iodo-imidazo[1,2-a]pyridine | HCID 67001159 | — |
| Product | 5-[6-(4-Chloro-phenyl)-8-fluoro-imidazo[1,2-a]pyridin-3-ylethynyl]-pyridin-2-ylamine | HCID 67001106 | — |
Reaction Steps
The title compound was prepared from 6-(4-chloro-phenyl)-8-fluoro-3-iodo-imidazo[1,2-a]pyridine (example C.30 step 2) (300 mg, 0.8 mmol) and 5-ethynyl-pyridin-2-ylamine (example D.1) (114 mg, 0.8 mmol) according to general procedure II. Obtained as a light brown solid (170 mg, 58%). MS (ISP) 363.2 [(M+H)+], 365 [(M+2+H)+]; mp 259° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063048B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-2058faaca65444c5beafec17ac543830 |
| Source note | uspto-grants-2011_11 |