Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Bromo-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-2-thiophenesulfonamide → 5-[7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-thiophene-2-sulfonic acid (2-hydroxy-1-hydroxymethyl-ethyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Bromo-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-2-thiophenesulfonamide | HCID 65314645 | — |
| 반응물 | 3-Ethynyl-7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine | HCID 86608034 | — |
| 생성물 | 5-[7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-thiophene-2-sulfonic acid (2-hydroxy-1-hydroxymethyl-ethyl)-amide | HCID 67000751 | — |
반응 단계
The title compound was prepared from 7-difluoromethyl-3-ethynyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.2) (169 mg, 0.5 mmol) and 5-bromo-thiophene-2-sulfonic acid (2-hydroxy-1-hydroxymethyl-ethyl)-amide (example B.54) (158 mg, 0.5 mmol) according to general procedure II. Obtained as a light brown solid (53 mg, 18%). MS (ISN) 571.0 [(M−H)−]; mp 152° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063048B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-3bc5fb3e9dbb430982631ff9d9de270f |
| 출처 메모 | uspto-grants-2011_11 |