Trifluoroacetic acid → 5-[(2-Methoxy-ethylamino)-methyl]-pyridin-3-ylamine

Participants

Reaction Steps

To a stirred solution of 56 (0.4 g, 1.42 mmol) in DCM (3 mL) was added TFA (3 mL) at 0° C. and stirred at rt for 3 h. The reaction mixture was concentrated, the residue was dissolved in MeOH, basified with Ambersep 900-OH resin, filtered to separate the resin and the filtrate concentrated to obtain the desired amine (90 mg, 88%) as a brown color viscous liquid. Rf: 0.1 (10% MeOH/CHCl3); (m/z):182 [M+1]+; 1H NMR (400 MHz, DMSO-d6) δ 7.77 (1H, d, J=2.4 Hz), 7.66 (1H, d, J=1.6 Hz), 6.86 (1H, d, J=2 Hz), 5.19 (2H, m), 3.66 (2H, s), 3.39-3.36 (3H, m), 3.22 (3H, s), 2.62-2.59 (2H, m), 1.93-1.92 (1H, br s).

Provenance & Evidence