5-Ethynylpyridin-2-amine → [3-(6-Amino-pyridin-3-ylethynyl)-5-(4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol

Participants

Role	Name	HCID	Charge
Reactant	5-Ethynylpyridin-2-amine	HCID 21954827	—
Reactant	[5-(4-Chloro-phenyl)-3-iodo-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol	HCID 67001059	—
Product	[3-(6-Amino-pyridin-3-ylethynyl)-5-(4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol	HCID 67001053	—

Reaction Steps

The title compound was prepared from [5-(4-chloro-phenyl)-3-iodo-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol (example C.14 step 2) (193 mg, 0.5 mmol) and 5-ethynyl-pyridin-2-ylamine (example D.1) (59 mg, 0.5 mmol) according to general procedure II. Obtained as an orange solid (111 mg, 59%). MS (ISP) 376.4 [(M+H)+]; mp 215-217° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063048B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-563971023c6646dba3bed1921c431929
Source note	uspto-grants-2011_11