[5-(4-Chloro-phenyl)-3-iodo-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol → 2-(4-[5-(4-Chloro-phenyl)-7-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-propan-2-ol

Participants

Role	Name	HCID	Charge
Reactant	[5-(4-Chloro-phenyl)-3-iodo-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol	HCID 67001059	—
Reactant	2-(4-Ethynylphenyl)propan-2-ol	HCID 73012446	—
Product	2-(4-[5-(4-Chloro-phenyl)-7-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-propan-2-ol	HCID 11852311	—

Reaction Steps

The title compound was prepared from [5-(4-chloro-phenyl)-3-iodo-pyrazolo[1,5-a]pyrimidin-7-yl]-methanol (example C.14 step 2) (193 mg, 0.5 mmol) and 2-(4-ethynyl-phenyl)-propan-2-ol (example D.4) (80 mg, 0.5 mmol) according to general procedure II. Obtained as a yellow solid (97 mg, 46%). MS (ISP) 418.1 [(M+H)+]; mp 118-120° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063048B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-1bbc94534aac43568d6905b182f96413
Source note	uspto-grants-2011_11