5-(4-Chloro-phenyl)-7-cyclopropyl-3-iodo-pyrazolo[1,5-a]pyrimidine → 2-(4-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-propan-2-ol

Participants

Role	Name	HCID	Charge
Reactant	5-(4-Chloro-phenyl)-7-cyclopropyl-3-iodo-pyrazolo[1,5-a]pyrimidine	HCID 67000875	—
Reactant	2-(4-Ethynylphenyl)propan-2-ol	HCID 73012446	—
Product	2-(4-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-propan-2-ol	HCID 11852218	—

Reaction Steps

The title compound was prepared from 5-(4-chloro-phenyl)-7-cyclopropyl-3-iodo-pyrazolo[1,5-a]pyrimidine (example C.5 step 4) (198 mg, 0.5 mmol) and 2-(4-ethynyl-phenyl)-propan-2-ol (example D.4) (80 mg, 0.5 mmol) according to general procedure II. Obtained as a yellow solid (143 mg, 67%). MS (ISP) 428.3 [(M+H)+]; mp 148-150° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08063048B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-0d5dab25fac041a094c64f0c44e68997
Source note	uspto-grants-2011_11