2-Amino-5-bromopyridine → HCID 67001253, compound

HRID 558922Notes

Reaction equation

HRID 558922 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:11]([CH3:12])=[CH:10][C:9]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=3)=[N:8][C:7]=12)#[CH:2].[NH2:23][C:24]1[CH:29]=[CH:28][C:27](Br)=[CH:26][N:25]=1>>[CH3:12][C:11]1[N:6]2[N:5]=[CH:4][C:3]([C:1]#[C:2][C:27]3[CH:28]=[CH:29][C:24]([NH2:23])=[N:25][CH:26]=3)=[C:7]2[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:21])([F:22])[F:20])=[CH:15][CH:14]=2)[CH:10]=1

Participants

3

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 86608077HCID 86608077, compound

Product 1

HCID 67001253HCID 67001253, compound

Procedure

The title compound was prepared from 3-ethynyl-7-methyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.12) (151 mg, 0.5 mmol) and 2-amino-5-bromopyridine (87 mg, 0.5 mmol) according to general procedure II. Obtained as an orange solid (37 mg, 19%). MS (ISP) 394.0 [(M+H)+].

Sources & evidence

ORD record
ord-7fd85553a72e47a9a6a3a2bb6a87d5c8
Source dataset
uspto-grants-2011_11
Patent number
US08063048B2

Reaction notes

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