5-Ethynylpyridin-2-amine → HCID 67001026, compound

HRID 558924Notes

Reaction equation

HRID 558924 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH2:14][CH3:15])[N:11]3[N:16]=[CH:17][C:18](I)=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.[C:20]([C:22]1[CH:23]=[CH:24][C:25]([NH2:28])=[N:26][CH:27]=1)#[CH:21]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH2:14][CH3:15])[N:11]3[N:16]=[CH:17][C:18]([C:21]#[C:20][C:22]4[CH:23]=[CH:24][C:25]([NH2:28])=[N:26][CH:27]=4)=[C:10]3[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 219548275-Ethynylpyridin-2-amineHCID 67001086HCID 67001086, compound

Product 1

HCID 67001026HCID 67001026, compound

Procedure

The title compound was prepared 5-(4-chloro-phenyl)-7-ethyl-3-iodo-pyrazolo[1,5-a]pyrimidine (96 mg, 0.25 mmol) and 5-ethynyl-pyridin-2-ylamine (example D.1) (30 mg, 0.25 mmol) according to general procedure II. Obtained as a yellow solid (41 mg, 44%). MS (ISP) 374.3 [(M+H)+]; mp 205-206° C.

Sources & evidence

ORD record
ord-a64212706d4f4fd099b2e8ae0aacb126
Source dataset
uspto-grants-2011_11
Patent number
US08063048B2

Reaction notes

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