HCID 28345299, compound → HCID 67000799, compound

HRID 558928Notes

Reaction equation

HRID 558928 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:11]([CH3:12])=[CH:10][C:9]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=3)=[N:8][C:7]=12)#[CH:2].[OH:23][CH2:24][CH2:25][NH:26][S:27]([C:30]1[S:31][C:32](Br)=[CH:33][CH:34]=1)(=[O:29])=[O:28]>>[OH:23][CH2:24][CH2:25][NH:26][S:27]([C:30]1[S:31][C:32]([C:2]#[C:1][C:3]2[CH:4]=[N:5][N:6]3[C:11]([CH3:12])=[CH:10][C:9]([C:13]4[CH:18]=[CH:17][C:16]([C:19]([F:21])([F:22])[F:20])=[CH:15][CH:14]=4)=[N:8][C:7]=23)=[CH:33][CH:34]=1)(=[O:29])=[O:28]

Participants

3

Reactant 2

HCID 28345299HCID 28345299, compoundHCID 86608077HCID 86608077, compound

Product 1

HCID 67000799HCID 67000799, compound

Procedure

The title compound was prepared from 3-ethynyl-7-methyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.12) (75 mg, 0.25 mmol) and 5-bromo-thiophene-2-sulfonic acid (2-hydroxy-ethyl)-amide (example B.59) according to general procedure II. Obtained as a yellow solid (87 mg, 68%). MS (ISP) 503.3 [(M+H)+]; mp 162-164° C.

Sources & evidence

ORD record
ord-54c0f5fb566a4211a7dc417998f6ad50
Source dataset
uspto-grants-2011_11
Patent number
US08063048B2

Reaction notes

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